One size does not fit all: notable individual variation in brain activity correlates of antidepressant treatment response.

ABSTRACT:

Introduction

To date, no robust electroencephalography (EEG) markers of antidepressant treatment response have been identified. Variable findings may arise from the use of group analyses, which neglect individual variation. Using a combination of group and single-participant analyses, we explored individual variability in EEG characteristics of treatment response.

Methods

Resting-state EEG data and Montgomery-Åsberg Depression Rating Scale (MADRS) symptom scores were collected from 43 patients with depression before, at 1 and 12 weeks of pharmacotherapy. Partial least squares (PLS) was used to: 1) identify group differences in EEG connectivity (weighted phase lag index) and complexity (multiscale entropy) between eventual medication responders and non-responders, and 2) dete

SUBMITTER: van der Wijk G 

PROVIDER: S-EPMC11018891 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature