MicroRNA analysis of medium/large placenta extracellular vesicles in normal and preeclampsia pregnancies.

ABSTRACT:

Background

Preeclampsia (PE) is a hypertensive disorder of pregnancy, affecting 2%-8% of pregnancies worldwide, and is the leading cause of adverse maternal and fetal outcomes. The disease is characterized by oxidative and cellular stress and widespread endothelial dysfunction. While the precise mechanisms are not entirely understood, the pathogenesis of PE is closely linked to placental dysfunction and, to some extent, syncytiotrophoblast extracellular vesicle release (STB-EVs). These vesicles can be divided into the less well-studied medium/large EVs (220-1,000 nm) released in response to stress and small EVs (<220 nm) released as a component of intercellular communication. The previously described production of m/lSTB-EVs in response to cellular stress combined with the overwhel

SUBMITTER: Awoyemi T 

PROVIDER: S-EPMC11018924 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature