Clinical significance of miR-9-5p in NSCLC and its relationship with smoking.

ABSTRACT:

Purpose

Dysregulated expression of microRNA (miRNAs) in lung cancer has been wildly reported. The clinicopathologic significance of miR-9-5p in non-small-cell lung cancer (NSCLC) patients and its effect on NSCLC progression were explored in this study.

Patients and methods

A total of 76 NSCLC patients were included. miR-9-5p expression was evaluated by real-time quantitative polymerase chain reaction (RT-qPCR). Then, in vitro experiments including cell growth curve assays, colony formation assays, and transwell migration assays were performed. Further clinicopathological and prognostic values were explored using bioinformatics analysis of the TCGA database.

Results

miR-9-5p expression was significantly increased in tumor tissues (both P < 0.0001). miR-9-

SUBMITTER: Zhang TX 

PROVIDER: S-EPMC11018953 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature