Characterization of a novel fast-growing zebrafish: a new approach to growth hormone transgenesis.

ABSTRACT: The manipulation of the somatotropic axis, governing growth, has been a focus of numerous transgenic approaches aimed at developing fast-growing fish for research, medicine and aquaculture purposes. However, the excessively high growth hormone (GH) levels in these transgenic fish often result in deformities that impact both fish health and consumer acceptance. In an effort to mitigate these issues and synchronize exogenous GH expression with reproductive processes, we employed a novel transgenic construct driven by a tilapia luteinizing hormone (LH) promoter. This approach was anticipated to induce more localized and lower exogenous GH secretion. In this study, we characterized the growth and reproduction of these transgenic LHp-GH zebrafish using hormonal and physiological parameters. Our

SUBMITTER: Cohen-Rothschild N 

PROVIDER: S-EPMC11018968 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature