Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis.

ABSTRACT: Over 50 genetic human disorders are attributed to the irregular expansion of microsatellites. These expanded microsatellite sequences can experience bidirectional transcription, leading to new reading frames. Beyond the standard AUG initiation or adjacent start codons, they are translated into proteins characterized by disease-causing amino acid repeats through repeat-associated non-AUG translation. Despite its significance, there's a discernible gap in comprehensive and objective articles on RAN translation. This study endeavors to evaluate and delineate the contemporary landscape and progress of RAN translation research via a bibliometric analysis. We sourced literature on RAN translation from the Web of Science Core Collection. Utilizing two bibliometric analysis tools, CiteSpace and VO

SUBMITTER: Zhao T 

PROVIDER: S-EPMC11019168 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature