Identification of qualitative characteristics of immunosuppression in sepsis based on immune-related genes and immune infiltration features.

ABSTRACT:

Objective

Sepsis is linked to high morbidity and mortality rates. Consequently, early diagnosis is crucial for proper treatment, reducing hospitalization, and mortality rates. Additionally, over one-fifth of sepsis patients still face a risk of death. Hence, early diagnosis, and effective treatment play pivotal roles in enhancing the prognosis of patients with sepsis.

Method

The study analyzed whole blood data obtained from patients with sepsis and control samples sourced from three datasets (GSE57065, GSE69528, and GSE28750). Commonly dysregulated immune-related genes (IRGs) among these three datasets were identified. The differential characteristics of these common IRGs in the sepsis and control samples were assessed using the REO-based algorithm. Based on these differenti

SUBMITTER: Zeng N 

PROVIDER: S-EPMC11019180 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature