Integrated analysis of transcriptional changes in major depressive disorder: Insights from blood and anterior cingulate cortex.

ABSTRACT:

Background

Major depressive disorder (MDD) was involved in widely transcriptional changes in central and peripheral tissues. While, previous studies focused on single tissues, making it difficult to represent systemic molecular changes throughout the body. Thus, there is an urgent need to explore the central and peripheral biomarkers with intrinsic correlation.

Methods

We systematically retrieved gene expression profiles of blood and anterior cingulate cortex (ACC). 3 blood datatsets (84 MDD and 88 controls) and 6 ACC datasets (100 MDD and 100 controls) were obtained. Differential expression analysis, RobustRankAggreg (RRA) analysis, functional enrichment analysis, immune associated analysis and protein-protein interaction networks (PPI) were integrated. Furthermore, the key

SUBMITTER: Zhong X 

PROVIDER: S-EPMC11019182 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature