β-Glucan fragmentation by microfluidization and TNF-α-immunostimulating activity of fragmented β-glucans.

ABSTRACT: Fragmentation of β-glucans secreted by the fungus Ophiocordyceps dipterigena BCC 2073 achieved by microfluidization was investigated. The degree of β-glucan fragmentation was evaluated based on the average number of chain scissions (α). The effects on the α value of experimental variables like solid concentration of the β-glucan suspension, interaction chamber pressure, and number of passes through the microfluidizer were examined. Kinetic studies were conducted using the relationships of the α and suspension viscosity values with the number of passes. Evidence indicated that α increases with the interaction chamber pressure and the number of passes, whereas the solid concentration shows the inverted effect. Kinetic data indicated that the fragmentation rate increases with β-glucan

SUBMITTER: Nanta P 

PROVIDER: S-EPMC11019199 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature