Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease.

ABSTRACT:

Importance

Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement.

Objectives

To examine clinicopathologic and neuroimaging characteristics of disease heterogeneity in AD along a quantitative continuum using the corticolimbic index (CLix) to account for individuality of spatially distributed tangles found at autopsy.

Design, setting, and participants

This cross-sectional study was a retrospective medical record review performed on the Florida Autopsied Multiethnic (FLAME) cohort accessioned from 1991 to 2020. Data were analyzed from December 2022 to December 2023. Structural magnetic re

SUBMITTER: Kouri N 

PROVIDER: S-EPMC11019448 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature