Maternal pre-pregnancy overweight or obesity and risk of birth defects in offspring: Population-based cohort study.

ABSTRACT:

Introduction

Maternal obesity, a health condition increasingly prevalent worldwide, has been suggested to be associated with a higher risk of birth defects in offspring, whereas evidence from population-based data from China was largely lacking. Additionally, the role of gestational diabetes in the association between maternal obesity and birth defects remains unclear. We aimed to investigate the association of maternal pre-pregnancy overweight or obesity with any and different types of birth defects in offspring and the interaction between pre-pregnancy overweight or obesity and gestational diabetes.

Material and methods

We conducted a population-based cohort study including 257 107 singletons born between 2015 and 2021 in Longgang District, Shenzhen, China, using data from

SUBMITTER: Liu W 

PROVIDER: S-EPMC11019515 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature