Next Generation Chemiluminescent Probes for Antimalarial Drug Discovery.

ABSTRACT: Malaria is caused by parasites of the Plasmodium genus and remains one of the most pressing human health problems. The spread of parasites resistant to or partially resistant to single or multiple drugs, including frontline antimalarial artemisinin and its derivatives, poses a serious threat to current and future malaria control efforts. In vitro drug assays are important for identifying new antimalarial compounds and monitoring drug resistance. Due to its robustness and ease of use, the [³H]-hypoxanthine incorporation assay is still considered a gold standard and is widely applied, despite limited sensitivity and the dependence on radioactive material. Here, we present a first-of-its-kind chemiluminescence-based antimalarial drug screening assay. The effect of com

SUBMITTER: Hellingman A 

PROVIDER: S-EPMC11019541 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature