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Selective C-H Iodination of Weinreb Amides and Benzamides through Iridium Catalysis in Solution and under Mechanochemical Conditions.

ABSTRACT: The acid mediated ortho-iodination of Weinreb amides using a readily available catalyst is described. The selective ortho-iodination of Weinreb amides, challenging substrates in directed C-H activations, and also of benzamides is achieved. The process works under mild conditions and tolerates air and moisture, having a great potential for industrial applications. The methodology can be applied under mechanochemical conditions maintaining the reaction outcome and selectivity.

SUBMITTER: Sanz-Marco A

PROVIDER: S-EPMC11019638 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Selective C-H Iodination of Weinreb Amides and Benzamides through Iridium Catalysis in Solution and under Mechanochemical Conditions.

Sanz-Marco Amparo A Saavedra Beatriz B Erbing Elis E Malmberg Jesper J Johansson Magnus J MJ Martín-Matute Belén B

Organic letters 20231106 14

The acid mediated ortho-iodination of Weinreb amides using a readily available catalyst is described. The selective ortho-iodination of Weinreb amides, challenging substrates in directed C-H activations, and also of benzamides is achieved. The process works under mild conditions and tolerates air and moisture, having a great potential for industrial applications. The methodology can be applied under mechanochemical conditions maintaining the reaction outcome and selectivity. ...[more]

PMID: 37931032

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