The host transcriptional response to superinfection by influenza A virus and Streptococcus pneumoniae.

ABSTRACT: Secondary bacterial challenges during influenza virus infection "superinfection") cause excessive mortality and hospitalization. Here, we present a longitudinal study of bulk gene expression changes in murine lungs during superinfection, with an initial influenza A virus infection and a subsequent Streptococcus pneumoniae infection. In addition to the well-characterized impairment of the host response, we identified superinfection-specific alterations in the global transcriptional program that are linked to the host's ability to resist the pathogens. Particularly, whereas superinfected mice manifested an excessive rapid induction of the resistance-to-infection program, there was a substantial tissue-level rewiring of this program: upon superinfection, interferon-regulated genes were

SUBMITTER: Cohn O 

PROVIDER: S-EPMC11019783 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature