Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigation.

ABSTRACT: The human gut microbiota is a dynamic community of microorganisms that undergo variable changes over the entire life span. To thoroughly investigate the possible fluctuations of the microbiota throughout human life, we performed a pooled analysis of healthy fecal samples across different age groups covering the entire human life span. Our study integrated data from 79 publicly available studies and new stool samples from an Italian cohort, i.e., the Parma Microbiota project, resulting in 6,653 samples processed through the shotgun metagenomic approach. This approach has allowed species-level taxonomic reconstruction of the gut microbiota and investigation of its metabolic potential across the human life span. From a taxonomic point of view, our findings confirmed and detailed at species-le

SUBMITTER: Mancabelli L 

PROVIDER: S-EPMC11019788 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature