Estrogen-based hormonal therapy and the risk of thrombosis in COVID-19 patients.

ABSTRACT:

Objective

Estrogen-containing contraceptives and hormone replacement therapy are used commonly, however, the risks of venous and arterial thrombosis imparted by such medications during COVID-19 infection or other similar viral infections remain undescribed.

Methods

To assess the risk of venous and arterial thrombosis in patients receiving oral estrogen-containing therapy (ECT) with COVID-19 as compared to those receiving non-estrogen-based hormonal therapy, we conducted a multicenter cohort study of 991 patients with confirmed COVID-19 infection, 466 receiving estrogen-containing hormonal therapy, and 525 receiving progestin-only or topical therapy.

Results

The use of estrogen-containing therapy was found to significantly increase the risk of venous thromboembolism (V

SUBMITTER: LaVasseur C 

PROVIDER: S-EPMC11019854 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature