Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.

ABSTRACT: The high-risk clone Klebsiella pneumoniae ST307, associated with various carbapenem resistance genes, exhibits a global distribution and prevalence. However, in China, it has remained sporadic and has rarely been detected. In this study, we reported an outbreak caused by nine ST307 CRKP isolates harboring bla_NDM-5 in Shanghai, China, in 2022. We employed antimicrobial susceptibility testing, conjugation assay, whole-genome sequencing (WGS) and comparative genomics, phylogenetic analysis, and fitness and virulence comparison to further characterize the isolates causing the outbreak. Besides bla_NDM-5, these nine isolates co-carried bla_CTX-M-15 and bla_DHA-1, exhibiting nearly identical resistance profiles with high

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11019902 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature