Recent H9N2 avian influenza virus lost hemagglutination activity due to a K141N substitution in hemagglutinin.

ABSTRACT: The H9N2 avian influenza virus (AIV) represents a significant risk to both the poultry industry and public health. Our surveillance efforts in China have revealed a growing trend of recent H9N2 AIV strains exhibiting a loss of hemagglutination activity at 37°C, posing challenges to detection and monitoring protocols. This study identified a single K141N substitution in the hemagglutinin (HA) glycoprotein as the culprit behind this diminished hemagglutination activity. The study evaluated the evolutionary dynamics of residue HA141 and studied the impact of the N141K substitution on aspects such as virus growth, thermostability, receptor-binding properties, and antigenic properties. Our findings indicate a polymorphism at residue 141, with the N variant becoming increasingly prevalent in rec

SUBMITTER: Wen F 

PROVIDER: S-EPMC11019909 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature