Diversity and distribution of biosynthetic gene clusters in agricultural soil microbiomes.

ABSTRACT: Bacterial secondary metabolites serve as an important source of molecules for drug discovery. They also play an important function in mediating the interactions of microbial producers with their living environment and surrounding organisms. However, little is known about the genetic novelty, distribution, and community-level impacts of soil bacterial biosynthetic potential on a large geographic scale. Here, we constructed the first catalog of 11,149 biosynthetic gene clusters (BGCs) from agricultural soils across China and unearthed hidden biosynthetic potential for new natural product discovery from the not-yet-cultivated soil bacteria. Notably, we revealed soil pH as the strongest environmental driver of BGC biogeography and predicted that soil acidification and global climate change cou

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11019929 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature