Photodynamic Therapy of LD4-Photosensitizer Attenuates the Acute Pneumonia Induced by <i>Klebsiella pneumoniae</i>.

ABSTRACT: Klebsiella pneumoniae is a Gram-negative bacterium that induces acute lung injury (ALI) and inflammation in humans, necessitating immediate hospitalization and treatment. At present, the clinical treatment is largely dependent on hormones or antibiotics but is associated with drawbacks posed by the lack of eradication of the bacterium upon treatment and drug resistance. Therefore, there is an urgent need for novel and effective treatments. The current study investigated the treatment of K. pneumonia-induced ALI using a photosensitizer LD4 in conjunction with photodynamic therapy (PDT). The water content in the lungs (corresponding to edema) of a rat model of pneumonia induced by K. pneumoniae was reduced upon treatment with LD4-PDT. The counts of leukocyte, lymphocyte,

SUBMITTER: Tao Z 

PROVIDER: S-EPMC11020065 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature