STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner.

ABSTRACT:

Background

Colorectal cancer standed as a global health challenge, ranking third in cancer incidence and second in cancer-related deaths worldwide. A deeper understanding of the intricate mechanisms driving colorectal cancer development was pressing need. STK16 had garnered attention in recent researches, while its involvement in cancer had been minimally explored. c-MYC had emerged as a key player in cancer biology. Due to its complex structure, multifunctionality, and intricate interactions, directly inhibiting the activity of c-MYC proves to be challenging. Hence, current research was directing efforts towards modulating c-MYC expression levels.

Methods

Immunoblot, Immunohistochemistry and immunoprecipitation assays were conducted to assess the indicated protein expressio

SUBMITTER: Peng L 

PROVIDER: S-EPMC11020453 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature