Correlates and trajectories of relapses in relapsing-remitting multiple sclerosis.

ABSTRACT:

Background and aims

In people with relapsing-remitting multiple sclerosis (pwRRMS), data from studies on non-pharmacological factors which may influence relapse risk, other than age, are inconsistent. There is a reduced risk of relapses with increasing age, but little is known about other trajectories in real-world MS care.

Methods

We studied longitudinal questionnaire data from 3885 pwRRMS, covering smoking, comorbidities, disease-modifying therapy (DMT), and patient-reported outcome measures, as well as relapses during the past year. We undertook Rasch analysis, group-based trajectory modelling, and multilevel negative binomial regression.

Results

The regression cohort of 6285 data sets from pwRRMS over time showed that being a current smoker was associated with 43.

SUBMITTER: Young CA 

PROVIDER: S-EPMC11021238 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature