Construction and validation of a folate metabolism-related gene signature for predicting prognosis in HNSCC.

ABSTRACT:

Purpose

Metabolic reprogramming is currently considered a hallmark of tumor and immune development. It is obviously of interest to identify metabolic enzymes that are associated with clinical prognosis in head and neck squamous cell carcinomas (HNSCC).

Methods

Candidate genes were screened to construct folate metabolism scores by Cox regression analysis. Functional enrichment between high- and low-folate metabolism groups was explored by GO, KEGG, GSVA, and ssGSEA. EPIC, MCPcounter, and xCell were utilized to explore immune cell infiltration between high- and low-folate metabolism groups. Relevant metabolic scores were calculated and visually analyzed by the "IOBR" software package.

Results

To investigate the mechanism behind metabolic reprogramming of HNSCC, 2886 hum

SUBMITTER: Wang L 

PROVIDER: S-EPMC11021263 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature