Non-invasive quantification of ¹⁸F-florbetaben with total-body EXPLORER PET.

ABSTRACT:

Background

Kinetic modeling of ¹⁸F-florbetaben provides important quantification of brain amyloid deposition in research and clinical settings but its use is limited by the requirement of arterial blood data for quantitative PET. The total-body EXPLORER PET scanner supports the dynamic acquisition of a full human body simultaneously and permits noninvasive image-derived input functions (IDIFs) as an alternative to arterial blood sampling. This study quantified brain amyloid burden with kinetic modeling, leveraging dynamic ¹⁸F-florbetaben PET in aorta IDIFs and the brain in an elderly cohort.

Methods

¹⁸F-florbetaben dynamic PET imaging was performed on the EXPLORER system with tracer injection (300 MBq) in 3 individuals with Alzheimer's diseas

SUBMITTER: Holy EN 

PROVIDER: S-EPMC11021392 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature