Assembly of short amphiphilic peptoids into nanohelices with controllable supramolecular chirality.

ABSTRACT: A long-standing challenge in bioinspired materials is to design and synthesize synthetic materials that mimic the sophisticated structures and functions of natural biomaterials, such as helical protein assemblies that are important in biological systems. Herein, we report the formation of a series of nanohelices from a type of well-developed protein-mimetics called peptoids. We demonstrate that nanohelix structures and supramolecular chirality can be well-controlled through the side-chain chemistry. Specifically, the ionic effects on peptoids from varying the polar side-chain groups result in the formation of either single helical fiber or hierarchically stacked helical bundles. We also demonstrate that the supramolecular chirality of assembled peptoid helices can be controlled by modifyin

SUBMITTER: Zheng R 

PROVIDER: S-EPMC11021492 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature