BRAF^V600E-mutant metastatic NSCLC: disease overview and treatment landscape.

ABSTRACT: In this review, we cover the current understanding of BRAF mutations and associated clinical characteristics in patients with metastatic NSCLC, approved and emerging treatment options, BRAF sequencing approaches, and unmet needs. The BRAF^V600E mutation confers constitutive activity of the MAPK pathway, leading to enhanced growth, proliferation, and survival of tumor cells. Testing for BRAF mutations enables patients to be treated with therapies that directly target BRAF^V600E and the MAPK pathway, but BRAF testing lags behind other oncogene testing in metastatic NSCLC. Additional therapies targeting BRAF^V600E mutations provide options for patients with metastatic NSCLC. Emerging therapies and combinations under investigation could potentially overcome issues

SUBMITTER: Planchard D 

PROVIDER: S-EPMC11021522 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature