New treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses.

ABSTRACT: Metastatic colorectal cancer (CRC) is still in need of effective treatments. This study applies a holistic approach to propose new targets for treatment of primary and liver metastatic CRC and investigates their therapeutic potential in-vitro. An integrative analysis of primary and metastatic CRC samples was implemented for alternative target and treatment proposals. Integrated microarray samples were grouped based on a co-expression network analysis. Significant gene modules correlated with primary CRC and metastatic phenotypes were identified. Network clustering and pathway enrichments were applied to gene modules to prioritize potential targets, which were shortlisted by independent validation. Finally, drug-target interaction search led to three agents for primary and liver metastatic

SUBMITTER: Karaca C 

PROVIDER: S-EPMC11021540 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature