Aberrant brain-heart coupling is associated with the severity of post cardiac arrest brain injury.

ABSTRACT:

Objective

To investigate autonomic nervous system activity measured by brain-heart interactions in comatose patients after cardiac arrest in relation to the severity and prognosis of hypoxic-ischemic brain injury.

Methods

Strength and complexity of bidirectional interactions between EEG frequency bands (delta, theta, and alpha) and ECG heart rate variability frequency bands (low frequency, LF and high frequency, HF) were computed using a synthetic data generation model. Primary outcome was the severity of brain injury, assessed by (i) standardized qualitative EEG classification, (ii) somatosensory evoked potentials (N20), and (iii) neuron-specific enolase levels. Secondary outcome was the 3-month neurological status, assessed by the Cerebral Performance Category score [good

SUBMITTER: Hermann B 

PROVIDER: S-EPMC11021613 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature