Epigenome-wide association study identifies DNA methylation loci associated with handgrip strength in Chinese monozygotic twins.

ABSTRACT: Background: The decline in muscle strength and function with aging is well recognized, but remains poorly characterized at the molecular level. Here, we report the epigenetic relationship between genome-wide DNA methylation and handgrip strength (HGS) among Chinese monozygotic (MZ) twins. Methods: DNA methylation (DNAm) profiling was conducted in whole blood samples through Reduced Representation Bisulfite Sequencing method. Generalized estimating equation was applied to regress the DNAm of each CpG with HGS. The Genomic Regions Enrichment of Annotations Tool was used to perform enrichment analysis. Differentially methylated regions (DMRs) were detected using comb-p. Causal inference was performed using Inference about Causation through Examination of Familial Confound

SUBMITTER: Luo J 

PROVIDER: S-EPMC11021642 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature