CD11c⁺ B cells in relapsing-remitting multiple sclerosis and effects of anti-CD20 therapy.

ABSTRACT:

Objectives

B cells are important in the pathogenesis of multiple sclerosis. It is yet unknown which subsets may be involved, but atypical B cells have been proposed as mediators of autoimmunity. In this study, we investigated differences in B-cell subsets between controls and patients with untreated and anti-CD20-treated multiple sclerosis.

Methods

We recruited 155 participants for an exploratory cohort comprising peripheral blood and cerebrospinal fluid, and a validation cohort comprising peripheral blood. Flow cytometry was used to characterize B-cell phenotypes and effector functions of CD11c⁺ atypical B cells.

Results

There were no differences in circulating B cells between controls and untreated multiple sclerosis. As expected, anti-CD20-treated patien

SUBMITTER: El Mahdaoui S 

PROVIDER: S-EPMC11021659 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature