An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter.

ABSTRACT:

Background

Dietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms.

Objective

Our study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS).

Methods

We recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics. Peripheral blood was collected and evaluated for cortisol levels, glycemia, lipid profile, and insulin resistance; methylation of CpGs 40-47 of the 1F region of the NR3C1 gene was also measured. Factors associated with degree of methylation were evaluated using generalized linear models (p < 0.05). Lifestyl

SUBMITTER: Vieira TDS 

PROVIDER: S-EPMC11021719 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature