HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity.

ABSTRACT:

Background

Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to predict this hypersensitivity reaction. We aimed to evaluate the possible involvement of genes in cefaclor induced type I hypersensitivity.

Methods

Whole exome sequencing (WES) and HLA genotyping were performed in 43 patients with cefaclor induced type I hypersensitivity. In addition, homology modeling was performed to identify the binding forms of cefaclor to HLA site.

Results

Anaphylaxis was the most common phenotype of cefaclor hypersensitivity (90.69%). WES results show that rs62242177 and rs62242178 located in LIM

SUBMITTER: Park SY 

PROVIDER: S-EPMC11021981 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature