Whole-body water mass and kidney function: a Mendelian randomization study.

ABSTRACT:

Background

The morbidity and mortality of chronic kidney disease (CKD) are increasing worldwide, making it a serious public health problem. Although a potential correlation between body water content and CKD progression has been suggested, the presence of a causal association remains uncertain. This study aimed to determine the causal effect of body water content on kidney function.

Methods

Genome-wide association study summary data sourced from UK Biobank were used to evaluate single-nucleotide polymorphisms (SNPs) associated with whole-body water mass (BWM). The summary statistics pertaining to kidney function were extracted from the CKDGen consortium. The primary kidney function outcome measures included estimated glomerular filtration rate (eGFR), albuminuria, CKD stages

SUBMITTER: Wei X 

PROVIDER: S-EPMC11022284 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature