Study protocol: exercise training for treating major depressive disorder in multiple sclerosis.

ABSTRACT:

Background

Major depressive disorder (MDD) is prevalent, yet sub-optimally treated among persons with multiple sclerosis (MS). We propose that exercise training may be a promising approach for treating depression in persons with MS who have MDD. Our primary hypothesis predicts a reduction in depression severity immediately after an exercise training intervention compared with minimal change in an attention control condition, and the reduction will be maintained during a follow-up period.

Methods

This study involves a parallel-group, assessor-blinded RCT that examines the effect of a 4-month home-based exercise training intervention on depression severity in a sample of persons with MS who have MDD based on the MINI International Neuropsychiatric Interview. The primary outcom

SUBMITTER: Motl RW 

PROVIDER: S-EPMC11022372 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature