Association between the circulating very long-chain saturated fatty acid and cognitive function in older adults: findings from the NHANES.

ABSTRACT:

Background

Age-related cognitive decline has a significant impact on the health and longevity of older adults. Circulating very long-chain saturated fatty acids (VLSFAs) may actively contribute to the improvement of cognitive function. The objective of this study was to investigate the associations between arachidic acid (20:0), docosanoic acid (22:0), tricosanoic acid (23:0), and lignoceric acid (24:0) with cognitive function in older adults.

Methods

This study used a dataset derived from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). A total of 806 adults (≥ 60 years) were included who underwent comprehensive cognitive testing and plasma fatty acid measurements. Multivariable linear regression, restricted cubic spline (RCS), and interaction analys

SUBMITTER: Shen Y 

PROVIDER: S-EPMC11022414 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature