Pan-azole- and multi-fungicide-resistant Aspergillus fumigatus is widespread in the United States.

ABSTRACT: Aspergillus fumigatus is an important global fungal pathogen of humans. Azole drugs are among the most effective treatments for A. fumigatus infection. Azoles are also widely used in agriculture as fungicides against fungal pathogens of crops. Azole-resistant A. fumigatus has been increasing in Europe and Asia for two decades where clinical resistance is thought to be driven by agricultural use of azole fungicides. The most prevalent mechanisms of azole resistance in A. fumigatus are tandem repeats (TR) in the cyp51A promoter coupled with mutations in the coding region which result in resistance to multiple azole drugs (pan-azole resistance). Azole-resistant A. fumigatus has been isolated from patients in the United States (U.S.), but little is kno

SUBMITTER: Celia-Sanchez BN 

PROVIDER: S-EPMC11022549 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature