Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.

ABSTRACT:

Background

Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity. The production of inflammatory cytokines, such as IL-1β and IL-18, plays a key role in this process. While IL-1β promotes insulin resistance and diabetes, IL-18 regulates energy expenditure and food intake. Previous studies have suggested that caspase-1, activated by the Nlrp3 inflammasome in response to lipid excess, mediates IL-1β production, whereas activated by the Nlrp1b inflammasome in response to energy excess, mediates IL-18 production. However, this has not been formally tested.

Methods

Wild-type and caspase-1-deficient Balb/c mice, carrying the Nlrp1b1 allele, were fed with regular chow or a high

SUBMITTER: Roman-Dominguez L 

PROVIDER: S-EPMC11022623 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature