Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched Vascular Aging.

ABSTRACT: Chronic inflammation is increasingly considered as the most important component of vascular aging, contributing to the progression of age-related cardiovascular diseases. To delay the process of vascular aging, anti-inflammation may be an effective measure. The anti-inflammatory factor annexin A1 (ANXA1) is shown to participate in several age-related diseases; however, its function during vascular aging remains unclear. Here, an ANXA1 knockout (ANXA1^-/-) and an endothelial cell-specific ANXA1 deletion mouse (ANXA1^△EC) model are used to investigate the role of ANXA1 in vascular aging. ANXA1 depletion exacerbates vascular remodeling and dysfunction while upregulates age- and inflammation-related protein expression. Conversely, Ac2-26 (a mimetic peptide of ANXA1) supplem

SUBMITTER: You Q 

PROVIDER: S-EPMC11022713 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature