PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration.

ABSTRACT: The collective migration of keratinocytes during wound healing requires both the generation and transmission of mechanical forces for individual cellular locomotion and the coordination of movement across cells. Leader cells along the wound edge transmit mechanical and biochemical cues to ensuing follower cells, ensuring their coordinated direction of migration across multiple cells. Despite the observed importance of mechanical cues in leader cell formation and in controlling coordinated directionality of cell migration, the underlying biophysical mechanisms remain elusive. The mechanically-activated ion channel PIEZO1 was recently identified to play an inhibitory role during the reepithelialization of wounds. Here, through an integrative experimental and mathematical modeling approach, w

SUBMITTER: Chen J 

PROVIDER: S-EPMC11023636 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature