Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer.

ABSTRACT:

Importance

Early-onset cancer (diagnosed under 50 years of age) is associated with aggressive disease characteristics and its rising incidence is a global concern. The association between healthy lifestyle and early-onset cancer and whether it varies by common genetic variants is unknown.

Objective

To examine the associations between genetic risk, lifestyle, and risk of early-onset cancers.

Design setting and participants

We analyzed a prospective cohort of 66,308 white British participants who were under age 50 and free of cancer at baseline in the UK Biobank.

Exposures

Sex-specific composite total cancer polygenic risk scores (PRSs), a breast cancer-specific PRS, and sex-specific health-associated lifestyle scores (HLSs, which summarize smoking status, body m

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11023660 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature