Ketamine induces multiple individually distinct whole-brain functional connectivity signatures.

ABSTRACT:

Background

Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine's molecular mechanisms connect to its neural and behavioral effects.

Methods

We conducted a single-blind placebo-controlled study, with participants blinded to their treatment condition. 40 healthy participants received acute ketamine (initial bolus 0.23 mg/kg, continuous infusion 0.58 mg/kg/hr). We quantified resting-state functional connectivity via data-driven global brain connectivity and related it to individual ketamine-induced symptom variation and cortical gene expression targets.

Results

We found that: (i) both the neural and behavior

SUBMITTER: Moujaes F 

PROVIDER: S-EPMC11023699 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature