Proton Therapy Mediates Dose Reductions to Brain Structures Associated With Cognition in Children With Medulloblastoma.

ABSTRACT:

Purpose

Emerging evidence suggests proton radiation therapy may offer cognitive sparing advantages over photon radiation therapy, yet dosimetry has not been compared previously. The purpose of this study was to examine dosimetric correlates of cognitive outcomes in children with medulloblastoma treated with proton versus photon radiation therapy.

Methods and materials

In this retrospective, bi-institutional study, dosimetric and cognitive data from 75 patients (39 photon and 36 proton) were analyzed. Doses to brain structures were compared between treatment modalities. Linear mixed-effects models were used to create models of global IQ and cognitive domain scores.

Results

The mean dose and dose to 40% of the brain (D40) were 2.7 and 4.1 Gy less among proton-treated pa

SUBMITTER: Sienna J 

PROVIDER: S-EPMC11023754 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature