Neural and behavioural state switching during hippocampal dentate spikes.

ABSTRACT: Distinct brain and behavioural states are associated with organized neural population dynamics that are thought to serve specific cognitive functions^1-3. Memory replay events, for example, occur during synchronous population events called sharp-wave ripples in the hippocampus while mice are in an 'offline' behavioural state, enabling cognitive mechanisms such as memory consolidation and planning^4-11. But how does the brain re-engage with the external world during this behavioural state and permit access to current sensory information or promote new memory formation? Here we found that the hippocampal dentate spike, an understudied population event that frequently occurs between sharp-wave ripples¹², may underlie such a mechanism. We show that dentate spikes

SUBMITTER: Farrell JS 

PROVIDER: S-EPMC11023929 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature