Reverse causation between multiple sclerosis and psoriasis: a genetic correlation and Mendelian randomization study.

ABSTRACT: Observational studies have found a potential bidirectional positive association between multiple sclerosis and psoriasis, but these studies are susceptible to confounding factors. We examined the directionality of causation using Mendelian randomization and estimated the genetic correlation using the linkage disequilibrium score. We performed Mendelian randomization analysis using large-scale genome-wide association studies datasets from the International Multiple Sclerosis Genetics Consortium (IMSGC, 115,803 individuals of European ancestry) and FinnGen (252,323 individuals of European ancestry). We selected several Mendelian randomization methods including causal analysis using summary effect (CAUSE), inverse variance-weighted (IVW), and pleiotropy-robust methods. According to CAUSE and

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11024188 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature