Exploring the coordination chemistry of ruthenium complexes with lysozymes: structural and in-solution studies.

ABSTRACT: This study presents a comprehensive structural analysis of the adducts formed upon the reaction of two Ru(III) complexes [HIsq][trans-Ru^IIICl₄(dmso)(Isq)] (1) and [H₂Ind][trans-Ru^IIICl₄(dmso)(HInd)] (2) (where HInd-indazole, Isq-isoquinoline, analogs of NAMI-A) and two Ru(II) complexes, cis-[RuCl₂(dmso)₄] (c) and trans-[RuCl₂(dmso)₄] (t), with hen-egg white lysozyme (HEWL). Additionally, the crystal structure of an adduct of human lysozyme (HL) with ruthenium complex, [H₂Ind][trans-RuCl₄(dmso)(HInd)] was solved. X-ray crystallographic data analysis revealed that all studied Ru complexes, regardless of coordin

SUBMITTER: Oszajca M 

PROVIDER: S-EPMC11024358 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature