Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge.

ABSTRACT:

Introduction

Clostridioides difficile infection (CDI), as well as its etiology and pathogenesis, have been extensively investigated. However, the absence of suitable CDI animal models that reflect CDI symptoms and the associated gut microbiome changes in humans has limited research progress in this field. Thus, we aimed to investigate whether Mongolian gerbils, which present a range of human pathological conditions, can been used in studies on CDI. Methods: In this study, we infected Mongolian gerbils and two existing CDI model animals, mice and hamsters, with the hypervirulent ribotype 027 C. difficile strain, and comparatively analyzed changes in their gut microbiome composition via 16S rRNA gene sequencing.

Methods

In this study, we infected Mongolian gerbils and t

SUBMITTER: Wan S 

PROVIDER: S-EPMC11024471 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature