Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells.

ABSTRACT:

Introduction

Osteoporosis is a systemic age-related disease characterized by reduced bone mass and microstructure deterioration, leading to increased risk of bone fragility fractures. Osteoporosis is a worldwide major health care problem and there is a need for preventive approaches.

Methods and results

Apigenin and Rutaecarpine are plant-derived antioxidants identified through functional screen of a natural product library (143 compounds) as enhancers of osteoblastic differentiation of human bone marrow stromal stem cells (hBMSCs). Global gene expression profiling and Western blot analysis revealed activation of several intra-cellular signaling pathways including focal adhesion kinase (FAK) and TGFβ. Pharmacological inhibition of FAK using PF-573228 (5 μM) and TGFβ using SB

SUBMITTER: Ali D 

PROVIDER: S-EPMC11024792 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature