Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial.

ABSTRACT:

Importance

Although the results of A Study to Evaluate the Corvia Medical Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients with Heart Failure (REDUCE LAP-HF II) trial were neutral overall, atrial shunt therapy demonstrated potential efficacy in responders (no latent pulmonary vascular disease and no cardiac rhythm management device). Post hoc analyses were conducted to evaluate the effect of shunt vs sham stratified by responder status.

Objective

To evaluate the effect of atrial shunt vs sham control on cardiac structure/function in the overall study and stratified by responder status.

Design, setting, and participants

This was a sham-controlled randomized clinical trial of an atrial shunt device in heart failure with preserved ejection fraction

SUBMITTER: Patel RB 

PROVIDER: S-EPMC11024798 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature