Synthesis and Evaluation of [⁶⁴Cu]Cu-NOTA-HFn for PET Imaging of Transferrin Receptor 1 Expression in Nasopharyngeal Carcinoma.

ABSTRACT: As recurrent and metastatic nasopharyngeal carcinoma (NPC) is the most common cause of death among patients with NPC, there is an urgent clinical need for the development of precision diagnosis to guide personalized treatment. Recent emerging evidence substantiates the increased expression of transferrin receptor 1 (also known as cluster of differentiation 71, CD71) within tumor tissues and the inherent targeting capability of natural heavy-chain ferritin (HFn) toward CD71. This study aimed to synthesize and assess a radiotracer ([⁶⁴Cu]Cu-NOTA-HFn) designed to target CD71 for positron emission tomography (PET) imaging in an NPC tumor-bearing mouse model. The entire radiolabeling process of [⁶⁴Cu]Cu-NOTA-HFn was completed within 15 min with high yield (>98.5%) and high

SUBMITTER: Shen Y 

PROVIDER: S-EPMC11024937 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature