Motif-Raptor: a cell type-specific and transcription factor centric approach for post-GWAS prioritization of causal regulators.

ABSTRACT:

Motivation

Genome-wide association studies (GWASs) have identified thousands of common trait-associated genetic variants but interpretation of their function remains challenging. These genetic variants can overlap the binding sites of transcription factors (TFs) and therefore could alter gene expression. However, we currently lack a systematic understanding on how this mechanism contributes to phenotype.

Results

We present Motif-Raptor, a TF-centric computational tool that integrates sequence-based predictive models, chromatin accessibility, gene expression datasets and GWAS summary statistics to systematically investigate how TF function is affected by genetic variants. Given trait-associated non-coding variants, Motif-Raptor can recover relevant cell types and critical TFs

SUBMITTER: Yao Q 

PROVIDER: S-EPMC11025460 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature