GPR27 expression correlates with prognosis and tumor progression in gliomas.

ABSTRACT:

Backgrounds

Glioma is a highly aggressive type of brain tumor, and its prognosis is still poor despite recent progress in treatment strategies. G protein-coupled receptor 27 (GPR27) is a member of the G protein-coupled receptor family and has been reported to be involved in various cellular processes, including tumor progression. Nevertheless, the clinical potential and tumor-related role of GPR27 in glioma remain unknown. Here we aimed to explore the function and role of GPR27 in gliomas.

Methods

In the current study, we evaluated the expression and clinical significance of GPR27 in gliomas using data from The Cancer Genome Atlas (TCGA) datasets. We also conducted cellular experiments to evaluate the functional role of GPR27 in glioma cell growth.

Results

We found th

SUBMITTER: Cai C 

PROVIDER: S-EPMC11025540 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature